OncoCartograph: Integrative Multi-Omics Biomarker Prioritisation for Triple-Negative Breast Cancer

A reproducible, auditable pipeline for prioritising druggable biomarkers in triple-negative breast cancer (TNBC), integrating RNA-seq, DNA methylation, copy number, and mutation data from TCGA-BRCA via MOFA+. Includes a standalone composite scoring package (survival association + druggability evidence) and a pre-registered external validation against an independent cohort (GSE96058/SCAN-B). Full methodology, architecture decisions, and results — including an honestly-reported negative validation finding — are documented in the accompanying preprint (docs/manuscript.md). Code, data provenance, and a runnable Snakemake pipeline are included for full end-to-end reproducibility.