The Founding Excision Hypothesis: A Testable Physical Prediction of Bimodal X Chromosome Mass in Human Oocytes and the True Nature of the Barr Body (Executive Summary)

This Executive Summary outlines a novel, testable hypothesis proposing that the two X chromosomes in human females are not physically identical. We predict a bimodal mass distribution among X chromosomes in unfertilized oocytes, reflecting the existence of a "Giant X" (the Barr body) and a "Small x". A direct physical measurement—using flow karyotyping, single-chromosome mass spectrometry, or long-read sequencing—could falsify or support this model. The full theoretical framework is available in the attached manuscript. We welcome critique and collaboration.