amr28693/ppmi_entropy: V1.0

Entropy Decomposition of PPMI MDS-UPDRS Trajectories Authors/Creators Rodriguez, Anderson ORCID icon Description Record of the GitHub repository hosting analysis code for a Shannon-entropy decomposition of item-level MDS-UPDRS score distributions in the Parkinson's Precision Medicine Initiative (PPMI, formerly the Parkinson's Progression Markers Initiative). For each MDS-UPDRS Part and visit, the method computes the Shannon entropy of the population-level distribution of item scores and tests whether entropy trajectories diverge between groups in ways a total-score comparison cannot detect.

The analysis accompanying the preprint compares GBA1-associated PD against sporadic PD, stratifying the diagnosed PD cohort by GBA1 carrier status.

Note on data: The PPMI data are not redistributed in this repository. Download them from the PPMI portal (https://www.ppmi-info.org/access-data-specimens/download-data) (Data Use Agreement required) and place the CSV files in a data/ directory alongside the scripts.