scRiskDB: A Single-Cell Epigenomic Resource Linking Complex Traits to Regulatory Mechanisms across Human Tissues

Here we present scRiskDB, a comprehensive and user-friendly database that maps genetic risk variants to their downstream regulatory elements, target genes, and relevant cell types at single-cell resolution. By integrating GWAS with single cell datasets across 45 tissues and developmental stages, scRiskDB implements a variant-to-function framework that systematically outlines potential regulatory cascades from single nucleotide variants to cell-specific risk mechanisms. 

scRiskDB is accessible via http://scriskdb.cn/ and the shiny-based framework code for web builds is available on GitHub https://github.com/gefeiZ/scRiskDB.