The Tissue Governance Failure Framework (TGFF): Multi-Scale Command Collapse and the Emergence of Malignant Autonomy
Authors/Creators
Description
Version 2.0 of the Tissue Governance Failure Framework. Expands the core proposition of v1.0 into a complete architecture of governance collapse through six new principles:
1. Multi-Scale Governance Collapse Model (MGCM): four-tier command hierarchy with operational biomarkers enabling governance collapse scoring via the Governance Collapse Index (GCI).
2. Local Emergency Sovereignty (LES): when central command fails, local tissues assume emergency authority — the governance root of Tactical Tolerance.
3. Brain Ceasefire Principle (BCP): the neuroimmune axis may act as a systemic survival arbitration layer that terminates total war when elimination cost threatens organismal survival.
4. Hierarchical Surrender Cascade (HSC): governance failure propagates upward through the command hierarchy.
5. Delayed Reawakening Principle (DRP): terminated wars resume when threat thresholds are breached.
6. Hematologic Null Model (HNM): hematologic malignancies lack localized tissue-governance architecture and therefore bypass containment-centered governance dynamics — explaining their unique curability.
New in v2.0: Governance Collapse Index (GCI) with weighted extension (wGCI), Bidirectional Governance Logic, operational biomarker matrix, four TikZ figures, 14 testable predictions, cross-framework integration with SPDS v5.0 and QCH v2.2, NHH hook for governance capture.
Together with SPDS v5.0 (Ignition Canon) and QCH v2.2 (Containment Canon), TGFF v2.0 completes the three-pillar core of the Abuamra Framework.
Files
Abuamra_MFY_TGFF_v2_0_2026_tex (1).pdf
Additional details
Additional titles
- Alternative title
- The Tissue Governance Failure Framework: A Unified Systems-Level Theory of Carcinogenesis — From Repair Exhaustion to Malignant Evolution
Related works
- Is supplement to
- Preprint: 10.5281/zenodo.20180050 (DOI)
- Preprint: 10.5281/zenodo.20623694 (DOI)
References
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