Cusrcumin Pharmacological property: A review on Anti-inflammatory activity and Human health

Abstract

              Turmeric has been documented as a spice and for its medicinal values; that attention has been made by both medicinal and culinary fanatics due to its polyphenol compound curcumin. It also worked as an antioxidant and anti-inflammatory, and other ailments include arthritis, diabetes, and cardiovascular diseases. Turmeric's major polyphenol compounds, curcuminoids, which include curcumin (diferuloyl methane), dimethoxy curcumin, and bisdemethoxycurcumin, have been evidenced as anti-inflammatory in human studies. The inflammation has shown different cascade mechanisms involving a number of molecules that are inhibited by curcumin, including cyclooxygenase-2, prostaglandin, phospholipase, lipoxygenase, thromboxane, nitric oxide, elastase, tumor necrosis factor (TNF), interleukin-12 (IL-12), monocyte chemoattractant protein-1 (MCP-1), and leukotrienes. The principal aim of this review paper is to evaluate curcumin's pharmacological anti-inflammatory properties in various diseases in humans with different mechanism of action.