NANOCATALYST-MEDIATED TETRAHYDROBENZO[B]PYRANS: REVIEW SYNTHESIS OF A COMPREHENSIVE

Abstract: Tetrahydrobenzo[b]pyrans, a class of highly valuable heterocyclic compounds, have garnered substantial consideration due to their different medicinal properties and synthetic versatility. Their structural features make them promising candidates for drug development, agrochemicals, and materials science. Now a day, the application of nanocatalysts in organic synthesis has emerged as a powerful and eco-friendly strategy, significantly enhancing reaction efficiency and selectivity. This review provides inclusive analysis of the latest progressions and preparation procedures of Tetrahydrobenzo[b]pyrans utilizing nanocatalysts. Discussion incorporates numerous nanocatalyst types, including metal nanoparticles (MNPs), metal oxides, metal-organic frameworks (MOFs), and organic-inorganic hybrids, highlighting their unique characteristics and catalytic performance. The synthetic routes reviewed herein incorporate both conventional and green chemistry approaches, underscoring the growing emphasis on sustainable practices in chemical synthesis. The review delves into the synthesis of tetrahydrobenzo[b]pyrans through diverse catalytic transformations, such as multi-component reactions, cycloadditions, and cascade reactions. The role of nanocatalysts in facilitating these transformations is meticulously examined, with an emphasis on their ability to accelerate reaction kinetics, enhance yield, and promote regio-selectivity and stereo-selectivity. Moreover, mechanistic insights into the catalytic processes are discussed, shedding light on the underlying interactions between the nanocatalysts and reactants. Additionally, the review highlights the importance of nanocatalyst stability and recyclability, critical factors for supportable synthesis. Keyword: Tetrahydrobenzo[b]pyrans; recyclability; sustainable synthesis; eco-friendly strategy