Herbosomal Gel Containing Manjistha (Rubia Cordifolia) And Turmeric (Curcuma Longa) For Psoriasis -A Detailed Review

Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by erythema, scaling, and keratinocyte hyperproliferation. The disease is mediated by cytokine pathways involving TNF-α, IL-17, and IL-23, and conventional therapies — including corticosteroids, methotrexate, and biologics — are associated with adverse effects and limited long-term safety. Herbal drugs such as Rubia cordifolia (Manjistha) and Curcuma longa (Turmeric) exhibit potent anti-inflammatory, antioxidant, and immunomodulatory activities; however, their poor bioavailability limits therapeutic efficacy in conventional formulations.Herbosomal drug delivery systems, which form phospholipid complexes with herbal phytoconstituents, enhance permeability, stability, and targeted skin delivery. This review comprehensively focuses on the role of herbosomal gel containing Manjistha and Turmeric in psoriasis treatment, encompassing formulation methodology, physicochemical evaluation, mechanisms of action, therapeutic advantages, and future prospects.