ConnectomeGuard: A Validation Framework for Multi-Site Diffusion MRI Connectomics

Reference implementation of the ConnectomeGuard validation framework for multi-site diffusion MRI (DTI) connectomics — the software accompanying Paper 1 (the Zero-Fingerprint Effect). It processes raw ABIDE-II DTI data through skull stripping, tensor estimation, CSA-ODF (constant solid angle) fiber-orientation computation, EuDX deterministic tractography, Schaefer-100 atlas registration, and 100x100 structural connectome construction, and implements the four ConnectomeGuard validation gates (cohort curation, preprocessing validation, tractography seed-saturation, and paired linear/nonlinear harmonization evaluation) together with edge- and network-level biomarker analysis. Demonstrated on 229 subjects across five ABIDE-II acquisition sites. Source repository: https://github.com/ConnectomeGuard/framework . Connectome matrices: https://doi.org/10.5281/zenodo.20812183 .