Lacuna: Cryptic Binding Pocket Discovery via Conformational Ensemble Analysis

Lacuna discovers cryptic binding pockets in proteins by generating a conformational ensemble, detecting pockets per conformer, clustering across the ensemble, and ranking by druggability with a continuous crypticity score. Validated on 20 cryptic-pocket targets (17/20, 85%), exceeding the CryptoSite benchmark. Uses an Anisotropic Network Model backend (CPU, ~1-8 s/protein) with optional Boltz-2 partial diffusion for harder targets.