Published June 20, 2026 | Version v1

Dataset from: 5-Methoxytryptophan attenuates inflammatory pain, modulates peripheral serotonin-immune signatures, and restores central serotonin transporter availability in male rats

Description

This dataset contains the processed RNA-seq count matrix and metadata, animal-level behavioral and paw-thickness source data, SERT PET region-of-interest (ROI) source data, all figure source tables, full gene-set/module membership definitions, and software-version information required to reproduce the figures and statistics reported in the associated manuscript "5-Methoxytryptophan attenuates inflammatory pain, modulates peripheral serotonin-immune signatures, and restores central serotonin transporter availability in male rats" (submitted to Brain, Behavior, and Immunity - Health).

Contents:
- Data Sheets S1–S2: RNA-seq metadata and count data
- Data Sheets S3–S9: Figure 2 source tables (PBMC inflammatory-neuroimmune signatures)
- Data Sheets S10–S12: Figure 3 rescue tables (M50 reversal of CFA-induced changes)
- Data Sheets S13–S15: Figure 4 serotonin-tryptophan-neuroimmune tables
- Data Sheets S16–S18: Figure 5 inflammatory and composition-sensitive module tables
- Data Sheets S19–S23: Figure 6 animal-level behavioral endpoint tables
- Data Sheets S24–S28: Figure 7 SERT PET and behavior-concordance tables
- Data Sheet S29: Full gene-set/module membership definitions

Raw RNA-seq sequencing data are separately deposited in NCBI GEO (accession number to be added).

Files

Files (15.3 MB)

Name Size
md5:7f5da2a89a693f265f40f6f8f730a271
15.3 MB Download

Additional details

Funding

Ministry of National Defense
MND-MAB-D-115129
Tri-Service General Hospital
TSGH_E_115270
National Science and Technology Council
NSTC 112-2314-B-016-066