Intravenous midazolam alters short-interval paired-pulse TMS responses differently in younger and older adults

This repository contains the de-identified dataset, data dictionary, and analysis code associated with the manuscript: “Intravenous midazolam alters short-interval paired-pulse TMS responses differently in younger and older adults.”

The study examined age-related differences in corticospinal excitability and short-interval paired-pulse transcranial magnetic stimulation (TMS) responses before and during intravenous midazolam administration. Fifteen younger adults aged 18-35 years and fifteen older adults aged 50-69 years underwent single-pulse and paired-pulse TMS of the left primary motor cortex. Single-pulse motor evoked potential (MEP) amplitude was used to quantify corticospinal excitability. Paired-pulse responses were quantified as the ratio of conditioned to unconditioned MEP amplitude.

The repository includes de-identified data needed to reproduce the primary analyses reported in the manuscript, including age group, stimulation condition, drug condition, single-pulse MEP amplitudes, paired-pulse MEP amplitudes, paired-pulse ratios, trial inclusion indicators, and interpolation/exclusion information where applicable. No direct identifiers, dates of birth, medical record numbers, contact information, or exact testing dates are included.

Files included in this repository:

1. subject_level_data.csv: De-identified participant-level summary dataset used for primary analyses.

2. trial_level_data.csv: De-identified trial-level MEP dataset, if permitted by institutional and ethical data-sharing restrictions.

3. data_dictionary.csv: Variable names, descriptions, coding definitions, and units.

4. analysis_code: Code used to reproduce the primary statistical analyses and summary tables.

5. README.txt: Overview of the dataset structure, file descriptions, and instructions for reproducing the analyses.

These data are provided to support transparency, reproducibility, and secondary analysis of the reported findings. Users should cite the associated manuscript and this repository when using these data.