A Magnetic Actuator-Based Platform for Functional Assessment of 3D Human Skeletal Muscle Bioengineered Tissues in Myotonic Dystrophy

3D bioengineered tissues has emerged as a relevant approach to develop more relevant biological models compared to traditional 2D cultures. It has previously been demonstrated that controlling the cellular microenvironment can enhance tissue morphogenesis, cell differentiation, and functionality. We aim to devellop magnetic actuator-based platforms that can reproduce DM1 phenotypes and induce percussive myopathy. To achieve this, we are designing chips with flexible pillars with magnetic nanoparticles to support 3D tissues and to generate this deflection, we are developing a magnetic actuation system based on electromagnets.