NEURON + Python model of striatal projection neurons for Belal et al. 'Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models'

Initial public release of the model code and documentation for the Belal et al. 2026 study.

This release includes:

A NEURON + Python model of striatal projection neurons (dSPN and iSPN).
Python simulation notebooks for generating the simulation data underlying manuscript Figures 4–6 and S1–S4.
Python analysis notebooks and helper functions (master_functions.py, analysis_functions.py, settings.py) for analysing simulation output and producing the manuscript figures, voltage/current-density traces, and 3D voltage heat maps.
Reconstructed SPN morphologies (.swc) and a figure map (figure map.json) linking each manuscript panel to its simulation and analysis notebooks.
Movie/animation versions of selected dendritic and somatic voltage simulations.
Documentation for Conda/Python environment setup (macOS/Linux/Windows), running simulations in Jupyter Notebook, downsampling, and the example analysis workflow.
An environment.yml file for recreating the Python analysis environment.

Data availability:

The model is adapted from the publicly available Lindroos & Kotaleski (2020) striatal_SPN_lib codebase (ModelDB 266775).
Large/raw simulation output is generated locally and is not stored in this GitHub repository.
Local output folders such as downsample/ and analysis/ are intentionally ignored.

Notes:

This repository is intended to reproduce the model simulations and figure-generation workflows associated with the manuscript.