Published June 11, 2026
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The Tissue Governance Failure Framework: From Repair Exhaustion to Malignant Evolution — A Unified Systems-Level Theory of Carcinogenesis
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This paper presents the Tissue Governance Failure Framework (TGFF), a unified systems-level theory of carcinogenesis that integrates three previously published hypotheses by the same author into a single, coherent explanatory architecture. The framework proposes that malignant evolution is not fundamentally a disease of individual cells, but a disease of tissue governance — the progressive failure of the multicellular systems that coordinate repair, maintain cellular identity, enforce apoptotic compliance, and sustain immune surveillance. Structured in three sequential tiers (Repair Exhaustion, SPDS/Dual-Hit Transition, Quarantine Capsule and Extensions), the TGFF generates 17 specific, falsifiable predictions spanning molecular biology, cellular biology, tissue pathology, and clinical oncology.
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Abuamra_MFY_Tissue_Governance_Failure_Framework_v1_0_Final_2026 (1).pdf
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- The Tissue Governance Failure Framework: A Unified Systems-Level Theory of Carcinogenesis — From Repair Exhaustion to Malignant Evolution
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- Is supplement to
- Preprint: 10.5281/zenodo.20180050 (DOI)
- Preprint: 10.5281/zenodo.20623694 (DOI)
References
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