INCLIVA Biomedical Research Institute
Published June 11, 2026 | Version v1
Dataset Open

Results of eye-movement paramenters in control subjects and cirrhotic patients

Authors/Creators

  • 1. ROR icon INCLIVA Health Research Institute
  • 2. ROR icon Universitat de València
  • 3. Universitat de València Facultat d'Infermeria i Podologia
  • 4. ROR icon Hospital Arnau de Vilanova
  • 5. ROR icon Pushchino State Institute of Natural Sciences
  • 6. ROR icon Universidad Politécnica de Madrid

Description

Dataset in excel file.

Four groups of study:
Healthy control subjects (n=35)
Cirrhotic patients (n=118): 3 groups according to PHES score and psychometric tests: 
- Patients without minimal hepatic encephalopathy (NMHE patients) (n=40)
- Patients with minimal hepatic encephalopathy (MHE patients) (n=32)
- Patients without minimal hepatic encephalopathy but with early cognitive alterations (early-MHE patients) (n=46)

Eye movement analysis was performed using a gaze tracker based on the video-oculography technique, and analyzed with OSCANN software. Ten kinds of eye movements were evaluated in the following order: visually-guided saccades, memory-guided saccades, antisaccades, and smooth pursuit, all in both horizontal and vertical versions; sinusoidal smooth pursuit, and fixation tests were also included.  

Data generation methodology:

Eye movement analysis was performed using a gaze tracker based on the video-oculography technique, and analyzed with OSCANN software.
- Hernández E, Hernández S, Molina D, Acebrón R, García Cena C. OSCANN: Technical Characterization of a Novel Gaze Tracking Analyzer. Sensors. 2018;18:522. https://doi.org/10.3390/s18020522
- Casanova-Ferrer F, García-Cena CE, Gallego J-J, Fiorillo A, Urios A, Calvo-Córdoba A, et al. Minimal hepatic encephalopathy is associated to alterations in eye movements. Sci. Rep. 2022;12:16837. https://doi.org/10.1038/s41598-022-21230-3

Abstract

Cirrhotic patients classified by the Psychometric Hepatic Encephalopathy Score (PHES) as without minimal hepatic encephalopathy (MHE) could exhibit early cognitive alterations, which could be detected by eye movement analysis. The aims were to develop a score for detecting these early impairments in cirrhotic patients using specific psychometric tests and to identify which eye movement parameters could be used to detect them. 
Cirrhotic patients (n=118) and 35 controls completed psychometric tests and eye movement tests batteries. Using multivariate models, we developed a methodology based on several psychometric tests to determine an optimal set of parameters to detect early neurological alterations in cirrhotic patients that PHES classified as without MHE. 
We found that 53.5% of these patients exhibited poorer cognitive performance (early-MHE patients), together with eye movement alterations, particularly in the antisaccades and fixation tests, which worsened in MHE patients, suggesting a spectrum of cognitive impairment severity between patients without MHE to those with MHE. The best predictive capacity for impaired cognitive function using eye movement tests was achieved including antisaccades test variables in multivariate model. 
Eye movements are useful for detecting, quickly and easily, subtle neurological alterations, which present a significant percentage of cirrhotic patients, improving the treatment and prognosis of cognitive impairment in these patients

Files

202603 plantilla Readme_Montoliu.txt

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Additional details

Funding

Instituto de Salud Carlos III
Acción Estratégica de Salud PI23/00062
Generalitat Valenciana
Consolidacio Cadena Valor
Generalitat Valenciana
Prometeo CIPROM2021/082
Institute of Theoretical and Experimental Biophysics
075-00224-24-03

Dates

Collected
2018-04-26/2024-07-12
Experimental phase