Published June 11, 2026
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CNS metastasis in humans with breast cancer represents a primed hESC state.
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Description
Elucidation of the primed hESC state recalled CNS metastasis genes including the central nuclear factor mediating CNS metastasis, Sox11, a second Sox homeobox factor family member, Sox21, as well as the Zic family of epigenetic imprinting effectors (Zic3, Zic5) whose expression defines metastasis to the CNS in humans with HER2+ breast cancer.