Preparation and Evaluation of Candesartan Fast Dissolving Tablets for Improved Dissolution Using Solid Dispersion Technique

The current investigation aimed to enhance their aqueous absorption and candesartan dissolving Kinetics, the drug is classified as an antihypertensive agent in class II, through the developing tablets that dissolve quickly, employing the solid-dispersion approach. Solid-dispersions of candesartan were fabricated via the solvent-evaporation technique utilizing hydrophilic polymeric carriers such as Poloxamer 407, PVP K30, and PEG 4000. The optimized dispersions were subsequently incorporated into tablet matrices using highly efficient superdisintegrants-Crospovidone as well as Sodium starch glycolate, through the direct compression methodology. Then the prepared formulations which have been characterized to micromeritic details and invitro disintegration in addition to dissolution performance. Among the developed formulations, batch F2 containing Crospovidone exhibited the most rapid disintegration and achieved approximately 98.85 % cumulative drug release within 45 minutes, signifying a pronounced enhancement in dissolution efficiency relative to the pure drug. FTIR spectral analysis confirmed by the absence of physicochemical incompatibility between drug and the ingredients, confirming development stability. Therefore, optimized solid dispersion system constitutes a promising and scientifically robust strategy for augmenting solubility, dissolution behavior, and oral bioavailability of candesartan, thereby enhancing therapeutic efficacy and patient compliance