nelacye/latent-current-trigger: Structure-Informed In Silico Stress Testing of Latent Ion-Current Triggers in Developmentally Gated SADS Vulnerability

This repository tests whether a latent, structure-informed hypothetical current (I_new) could be electrophysiologically silent at baseline but become destabilizing under stress (calcium, pacing, mutation shifts, developmental transition). It embeds I_new into human ventricular action-potential models (ORd/O'Hara-Rudy) and quantifies instability via EADs, DADs, spontaneous APs, alternans, and calcium transient metrics. The framework samples virtual cells across parameter uncertainty, stress protocols, and a maturation axis (immature-like to adult-like).