PREPARATION AND EVALUATION OF THERMOSENSITIVE NASAL GELS OF LORATADINE FOR THE EFFECTIVE MANAGEMENT OF ALLERGIC CONDITIONS.

Abstract
Allergic rhinitis is a common inflammatory disorder affecting the nasal mucosa and
significantly reducing quality of life. The present study focused on the formulation and
evaluation of thermosensitive nasal gel of loratadine for improved intranasal drug delivery.
Thermosensitive nasal gels were prepared using Poloxamer 407 as thermoreversible polymer
along with mucoadhesive polymers such as Carbopol 934P and HPMC. The formulations
were prepared by cold method and evaluated for physicochemical parameters including pH,
gelation temperature, viscosity, drug content, mucoadhesive strength, spreadability, in-vitro
gelation, and drug release studies. The optimized formulation exhibited satisfactory gelation
temperature near physiological nasal temperature, good mucoadhesive properties, and
sustained drug release profile over 6 hours. Stability studies confirmed that the formulation
remained stable under accelerated conditions. The developed thermosensitive nasal gel of
loratadine may serve as an effective alternative to conventional dosage forms by improving
nasal residence time, bioavailability, patient compliance, and therapeutic efficacy in allergic
rhinitis management.