Microbes as Architects of Life: The Microbial Integration Architecture Theory (MIAT)
Published June 6, 2026 | Version Version: 1.0
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Microbial Integration Architecture Theory (MIAT) Atlas: An Ecological Atlas of Human Biology

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Microbial Integration Architecture Theory (MIAT): An Ecological Atlas of Human Biology

This preprint presents the first atlas-based representation of the Microbial Integration Architecture Theory (MIAT), a conceptual framework that interprets human biology as a multi-layered ecological architecture rather than a collection of isolated cellular and organ-level processes.

The atlas organizes biological organization into five interconnected domains:

• Structural Architecture
• Anatomical Architecture
• Physiological Architecture
• Mechanistic Architecture
• Developmental Architecture

Within this framework, microbial activity, extracellular organization, energetic regulation, and cellular execution are interpreted as interdependent layers that collectively shape biological function. The atlas further introduces the concepts of regenerative coherence and degenerative incoherence as system-level patterns describing adaptive and maladaptive biological organization.

Rather than proposing a replacement for existing biological models, MIAT is intended as an integrative conceptual framework that extends perspectives from systems biology, microbiome research, extracellular matrix biology, developmental biology, and psychoneuroimmunology.

This work is presented as a theoretical and interpretive atlas designed to support future discussion, hypothesis generation, computational modeling, and empirical investigation of ecological approaches to human biology.

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Subtitle (English)
A Systems-Level Framework Integrating Microbiome, Energy, and Development

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Submitted
2026-06-06
Microbial Integration Architecture Theory (MIAT): An Ecological Atlas of Human Biology This preprint presents the first atlas-based representation of the Microbial Integration Architecture Theory (MIAT), a conceptual framework that interprets human biology as a multi-layered ecological architecture rather than a collection of isolated cellular and organ-level processes. The atlas organizes biological organization into five interconnected domains: • Structural Architecture • Anatomical Architecture • Physiological Architecture • Mechanistic Architecture • Developmental Architecture Within this framework, microbial activity, extracellular organization, energetic regulation, and cellular execution are interpreted as interdependent layers that collectively shape biological function. The atlas further introduces the concepts of regenerative coherence and degenerative incoherence as system-level patterns describing adaptive and maladaptive biological organization. Rather than proposing a replacement for existing biological models, MIAT is intended as an integrative conceptual framework that extends perspectives from systems biology, microbiome research, extracellular matrix biology, developmental biology, and psychoneuroimmunology. This work is presented as a theoretical and interpretive atlas designed to support future discussion, hypothesis generation, computational modeling, and empirical investigation of ecological approaches to human biology.

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