Dataset for the project "Brain synchronization to treat early stage Alzheimer Disease – BrainSync –AD" European Union—Next Generation EU—NRRP M6C2—Investment 2.1 Enhancement and strengthening of biomedical research in the NHS (PNRRPOC-2022–12376021) - Cup Code: G55E22001130001

Dataset for the project “Brain synchronization to treat early stage Alzheimer Disease – BrainSync –AD” European Union—Next Generation EU—NRRP M6C2—Investment 2.1 Enhancement and strengthening of biomedical research in the NHS (PNRRPOC-2022–12376021) - Cup Code: G55E22001130001

PI: Enrico Premi

1) ASST Spedali Civili di Brescia

2) Fondazione Istituto G. Giglio, Cefalù (PA) – PI Dr.ssa Graziella Callari

3) Università degli Studi di Ferrara – PI Prof. Giacomo Koch

4) Azienda Ospedaliera Universitaria Policlinico Tor Vergata – PI Prof. Alessandro Martorana

AIM1

To assess safeness, tolerability and clinical efficacy of multisession gamma-tACS over the precuneus in at-home setting.

Aims: a) To demonstrated safety and tolerability of multisession gamma-tACS over the precuneus in at-home setting; b) To evaluate the short term and long-lasting effects of multisession gamma-tACS on cognitive performances and whether repetition of multisession g-tACS may further outlast intervention efficacy; c) To identify predictors of gamma-tACS efficacy in AD patients.

AIM2

To assess entrainment and neurophysiological effects of multisession gamma-tACS over the precuneus in AD.

Aims: a) To evaluate the effects of multisession gamma-tACS on brain entrainment in AD; b) To evaluate the effects of multisession gamma-tACS on cholinergic circuits in AD.

AIM3

To assess biological effects of multisession gamma-tACS over the precuneus in AD.

Aims: a) To assess the effects of multisession gamma-tACS on pathophysiological markers of AD, considering measures of amyloidosis and neurodegeneration; b) To demonstrate that multisession gamma-tACS induces changes in functional brain connectivity within the default mode network (DMN).

The present dataset contains:

·         an excel file containing ID, treatment, sex, age, age at onset, education, NPS evaluation, TMS data, biological markers (Aβ1-42, Aβ1-40, NfL, GFAP, and p-tau217), EEG data and EV data;

·         a folder containing fMRI image

Users must clarify how they intend to use data here uploaded and whether the research protocol has been approved by an Ethics committee. Data on unpublished results will be available, under the same restrictions, after publication.