Prim‑Lex Medicine · HIV/AIDS Therapeutics: A Systematic Diagnostic and Therapeutic Revolution from Metabolic Decoherence to Eight‑Dimensional Coherent State

Based on the eight‑dimensional framework of Prim‑Lex theory, this paper redefines HIV/AIDS as “an irreversible phase transition of the immune‑systemic system from a global coherent state to a localized decoherent state.” HIV infection is not a single viral attack but a collective phase transition of the eight‑dimensional system: Prim‑Unity·Prim‑Fire (decoherence of the NADH/NAD⁺ redox couple in CD4⁺ T cells, collapse of mitochondrial metabolism) → Two Principles·Yin‑Yang (polarization between the “hyperactivity” of viral replication and the “deficiency” of CD4⁺ T‑cell apoptosis) → Three Realms·GC⁴A (cross‑scale infection decoherence from host cells to immune tissues to systemic organs) → Four Phenomena·Four Colors (differentiated interventions for viral reservoir quiescent, replicating, activated, and exhausted phases) → Five Elements·Five Models (quintuple coupling of metabolic deficit, latent phase transition, spatial zoning, immunometabolic balance sheet, and immune resilience) → Six Dimensions·Six Directions (topological decoherence of the spatial distribution of CD4⁺ T cells in lymphoid tissues) → Seven Luminaires·Seven Rhythms (circadian regulation of viral replication and immune responses) → Eight Trigrams·Eight Information (entropy explosion of the immune‑neuro‑endocrine information network – the quantum origin of HIV‑associated neurocognitive disorders). This paper systematically elaborates the pathological manifestations, diagnostic methods, and targeted therapeutic strategies for each dimension, demonstrates the scientific validity of the eight‑dimensional coherent‑state criterion  as a unified benchmark for HIV/AIDS diagnosis, efficacy evaluation, and functional cure, and proposes a five‑tier pathway for “life‑cycle HIV/AIDS prevention – pre‑exposure prophylaxis · early screening · critical window intervention · systematic antiretroviral therapy · functional cure,” thereby completing the scale bridging of Prim‑Lex theory from “planetary civilization governance” to “immune health governance.”