Lacuna: Cryptic Binding Pocket Discovery via Conformational Ensemble Analysis

Lacuna discovers cryptic binding pockets in proteins by generating a conformational ensemble, detecting pockets per conformer, clustering across the ensemble, and ranking by persistence and druggability. Validated on 20 cryptic-pocket targets (14/20, 70%), matching the CryptoSite benchmark. Supports RandomBackend (CPU, ~1–4 s/protein) and Boltz-2 partial diffusion for harder targets.