Formulation and Evaluation of Polyherbal Orodispersible Tablets for Antidiabetic Activity

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The present study aimed to formulate and evaluate polyherbal orodispersible tablets for antidiabetic activity using herbal ingredients such as Syzygium cumini, Phyllanthus emblica, Ocimum sanctum, Clitoria ternatea, and Cinnamomum zeylanicum. Herbal extracts were prepared by maceration method using hydroalcoholic solvent system and tablets were pre pared by direct compression method using crospovidone as superdisintegrant. The prepared formulations were evaluated for preformulation and post-compression parameters including angle of repose, bulk density, tapped density, hardness, friability, disintegration time, wetting time, drug content, and in-vitro dissolution studies. Among all formulations, F3 showed the best performance with rapid disintegration and maximum drug release. The study concluded that the developed polyherbal orodispersible tablets possess promising antidiabetic potential with improved patient compliance and rapid onset of action.