Published June 2, 2026
| Version v1
Journal article
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Anatomical and physiological aspects of general anesthesia in neonates and infants under twelve months
Authors/Creators
Description
Anesthesia in neonates and infants under one year of age presents unique challenges to anesthesiologists due to the profound anatomical, physiological, and pharmacological differences between this age group and older children or adults. This article provides a comprehensive review of the critical clinical and physiological characteristics that dictate anesthetic management in early infancy. We examine the immature respiratory, cardiovascular, renal, and central nervous systems, highlighting how these factors influence the pharmacokinetics and pharmacodynamics of commonly used anesthetic agents.
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Additional details
Dates
- Accepted
-
2026-06-021
References
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- 3.Coté, C. J., Lerman, J., & Anderson, B. J. (2019). A Practice of Anesthesia for Infants and Children (6th ed.). Elsevier.
- 4.Volkov, A. V., & Saito, S. (2021). Physiological features of the neonatal airway and its implications for modern pediatric anesthesia. Journal of Anesthetic Clinic, 34(2), 112–119.
- 5.Cravero, J. P., Beach, S. M., & Blike, G. T. (2022). Adverse events during pediatric anesthesia and sedation: A progressive analysis of risk factors. Pediatric Anesthesia, 32(5), 588–597.