Published September 5, 2024
| Version v2
Dataset
Open
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
Authors/Creators
- 1. UNC Chapel Hill
-
2.
University of North Carolina at Chapel Hill
Description
These files contain the data described in Broadaway (2024), AJHG, PMID: 39173627.
Version 2 corrects an annotation-join issue in the previously uploaded files. A small number of signals from 5 genes were unintentionally excluded from Version 1 during file generation. Additionally, Version 1 files used formatting that differed from the Mohlke Lab website release. This corrected release restores the excluded genes and harmonizes the Zenodo files with the website release.
| Marginal eQTL summary stats: | |
| Column label | Description |
| Entrez | Entrez ID |
| Variant | Chromosome_position_NonEffectAllele_EffectAllele |
| CHR | Chromosome |
| POS | Position (hg19) |
| NEA | Non-effect allele |
| EA | Effect allele |
| EAF | Effect allele frequency |
| Beta | Effect size of association between variant and gene |
| SE | Standard error |
| PVAL | p-value of association between variant and gene |
| N | Sample size for variant |
| Studies | Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161) |
| GeneSymbol | Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110) |
| ENSG | Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110) |
| Gene_Biotype | Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110) |
| Files for download: | |
| Description | Marginal eQTL full summary statistics – all results by chromosome |
| Filename | Liver_eQTL_Meta_Marginal_20240530.tar.gz |
| Size | 1.9 GB |
| Date | 5/30/2024 |
| Isolated eQTL summary stats (each signal isolated): | ||
| Column label | Description | |
| GeneSymbol | Gene symbol: lookup biomaRt (version 2.50.3, Ensembl version 110) | |
| Entrez | Entrez ID | |
| SignalLead | Lead variant of isolated signal | |
| Variant | Chromosome_position_NonEffectAllele_EffectAllele | |
| NEA | Non-effect allele | |
| EA | Effect allele | |
| EAF | Effect allele frequency | |
| Beta | Effect size of association between variant and gene | |
| SE | Standard error | |
| PVAL | p-value of association between variant and gene | |
| N | Sample size for variant | |
| Studies | Studies with gene expressed. 1=Germany (145), 2=Schadt (555), 3=Merck (322), 4 = BLP (161) | |
| ENSG | Ensembl ID for gene: lookup biomaRt (version 2.50.3, Ensembl version 110) | |
| Gene_Biotype | Gene Biotype: lookup biomaRt (version 2.50.3, Ensembl version 110) | |
| Files for download: | Liver_eQTL_Meta_Isolated_20240530.tar.gz | |
| Description | Isolated conditional summary statistics for significant signals – all results by chromosome. Only genes for which >1 signal was detected are included in this isolated summary statistics dataset. For single-signal eGenes, refer to the marginal dataset. | |
| Filename | ||
| Size | 609 MB | |
| Date | 5/30/2024 |