Formulation And Evaluation Of Fast Disintegrating Losartan Potassium Tablets By Natural Excipients

The objective of the proposed research work is to prepare and evaluate the fast disintegrating losartan potassium tablets by natural excipients, which avoids first pass metabolism, improved the dissolution rate and enhance the bioavailability. Losartan potassium is angiotensin receptor antagonist, used in the management of hypertension. Fast disintegrating tablets were prepared by direct compression method by using different concentrations of super disintegrants like guar gum, Hibiscus Rosa, gum karaya, chitosan, banana powder, and fenugreek mucilage evaluated for physicochemical evaluation parameters such as hardness, friability, weight variation, and drug content uniformity, in-vitro dissolution studies, the six formulation, F1-F6 were formulated and among these formulations F1, was optimized. The hardness, friability, weight variation and drug content uniformity were found to be within pharmacopeias limits. The in-vitro drug release  from formulation containing super disintegrants fenugreek mucilage was found was found with 85.62±0.26 to 96.74±0.86 in 10min and the maximum drug release was found with F1 formulation. The disintegration studies shown all formulations disintegrated in less than 1min. the formulation F1shown less disintegration time of 17 seconds. The fenugreek mucilage and banana powder shown more disintegration time than guar gum. An FTIR studies was performed and data revealed that no interactions takes place between the drug and polymers used the optimized formulation. In conclusion, from the above study the formula used for F1formulation was concluded as optimized formulation due to its less disintegration time and good % drug release when compared with other formulation.