Formulation of Photo Shield Antioxidant Herbal Peel Off Mask: A Systemic Review
- 1. 1School of Pharmacy, Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida, Uttar Pradesh
Contributors
Contact person:
- 1. 1School of Pharmacy, Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida, Uttar Pradesh
Description
Abstract
Skin is continuously exposed to ultraviolet radiation, environmental pollutants, and oxidative stress, leading to premature aging, pigmentation, and loss of elasticity. This systematic review focuses on the development and evaluation of a "Photoshield" antioxidant herbal peel-off mask designed to provide photoprotection, detoxification, and skin rejuvenation. The study analyzes the role of plant-based antioxidants such as aloe vera, green tea, turmeric, neem, and vitamin C-rich extracts in neutralizing reactive oxygen species (ROS) and reducing inflammation. Data were collected from peer-reviewed journals and pharmaceutics databases to assess formulation strategies, particularly the use of polyvinyl alcohol (PVA) as a film-forming agent, along with evaluation parameters including pH, viscosity, drying time, spreadability, stability, and skin irritation. Findings indicate that herbal antioxidants effectively enhance skin protection, hydration, and collagen integrity, while the peel-off mechanism aids in deep cleansing by removing impurities and dead cells. Additionally, these formulations demonstrate better tolerability compared to synthetic alternatives. The review concludes that the Photoshield herbal peel-off mask represents a promising advancement in herbal cosmetology; however, further in vivo studies and stability assessments are required to validate its clinical efficacy and commercial potential.
Keywords
Antioxidant, Herbal peel-off mask, Photoprotection, Reactive oxygen species, Polyvinyl alcohol, UV radiation, Free radical scavenging, Skin rejuvenation, Herbal cosmetology.
Files
56-75-Formulation-Preeti Singh-1-8980740220.pdf
Files
(829.2 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:dbd4b5e9f60489026ed7a70c097a1f71
|
829.2 kB | Preview Download |
Additional details
References
- 1. Chaerunisaa AY, Khuzaimah Z, Surachman E. Peel-off gel mask containing green tea leaf extract (Camellia sinensis L.) with antioxidant activity. Indones J Pharm. 2021;3(1):1-8. doi:10.24198/idjp.v3i1.30946. 2. Rachmawati P, et al. Optimization of rosella extract-based antioxidant peel-off mask formulation. Cosmetics. 2025;12(2):45. doi:10.3390/cosmetics12020045. 3. Apriani EF, Miksusanti M, Fransiska N. Formulation and optimization of peel-off gel mask with polyvinyl alcohol and gelatin. Indones J Pharm. 2022;33(2):261-268. 4. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-1470. doi:10.1001/archderm.138.11.146 5. Tomas M, Günal-Köroğlu D, Kamiloglu S, Ozdal T, Capanoglu E. The state of the art in anti-aging: plant-based phytochemicals for skin care. Immun Ageing. 2025; 22:5. doi:10.1186/s12979-025-00498-9 6. Velasco MVR, Sarruf FD, Salgado-Santos IMN, Haroutiounian-Filho CA, Kaneko TM, Baby AR. Short-term clinical evaluation of peel-off facial masks' moisturizers. J Cosmet Dermatol. 2014;13(2):146-152. doi:10.1111/jocd.12086. 7. Birade P, et al. Formulation and evaluation of herbal peel-off mask. J Pharma Insights Res. 2024;2(1):92-96. 8. Moltrasio C, Romagnuolo M, Marzano AV. Epigenetic mechanisms of epidermal differentiation. Int J Mol Sci. 2022;23(9):4874. doi:10.3390/ijms23094874. 9. Möbus L, Weidinger S, Emmert H. Epigenetic factors involved in the pathophysiology of inflammatory skin diseases. J Allergy Clin Immunol. 2020;145(4):1049-1060. doi: 10.1016/j.jaci.2019.10.015. 10. Mohania D, Chandel S, Kumar P, Verma V, Digvijay K, Tripathi D, et al. Ultraviolet radiations: skin defense-damage mechanism. Adv Exp Med Biol. 2017; 996:71-87. doi:10.1007/978-3-319-56017-5_7. 11. Fonseca AP, Dal Pizzol C, Vanzo AC, Silva GH, Facchini G, Pinheiro ALT, et al. Anti-aging effects of a skin care formulation containing nanoencapsulated antioxidants: a clinical, in vitro, and ex vivo study. J Cosmet Dermatol. 2024;23(2):510-524. 12. Tang X, Yang T, Yu D, Xiong H, Zhang S. Current insights and future perspectives of ultraviolet radiation exposure: friends and foes to the skin and beyond the skin. Environ Int. 2024; 185:108535. doi: 10.1016/j.envint.2024.108535. 13. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2009;302(2):71-83. doi:10.1007/s00403-009-1001-3 14. Theile D, Geng S, Denny EC, Momand J, Kane SE. t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit. Cell Signal. 2017; 40:53-61. doi: 10.1016/j.cellsig.2017.08.012. 15. Harwansh RK, Deshmukh R. Recent insight into UV-induced oxidative stress and role of herbal bioactives in the management of skin aging. Curr Pharm Biotechnol. 2023;25(1):16-41. doi:10.2174/1389201024666230427110815. 16. Pacifico A, Leone G, Damiani G, Ferraro C, Iacovelli P, Paro Vidolin A, et al. Indeterminate cell histiocytosis: a case treated with ultraviolet B narrow band phototherapy. Photodermatol Photoimmunol Photomed. 2017;33(6):329-333. doi:10.1111/phpp.12327. 17. Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation. Int J Cosmet Sci. 2005;27(1):17-34. doi:10.1111/j.1467-2494.2004.00241. x. 18. Jin Z, Zhang P, Huang H, Liu J, Jiang C, Zhang H, et al. Food-derived skin-care ingredients as a promising strategy for skin aging: current knowledge and future perspectives. Colloids Surf B Biointerfaces. 2024; 244:114170. doi: 10.1016/j.colsurfb.2024.114170 19. Rizzardi N, Liparulo I, Antonelli G, Orsini F, Riva A, Bergamini C, et al. Coenzyme Q10 phytosome formulation improves CoQ10 bioavailability and mitochondrial functionality in cultured cells. Antioxidants (Basel). 2021;10(6):927. doi:10.3390/antiox10060927. 20. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2015;5(2):545-589. 21. Ngoc LTN, Moon JY, Lee YC. Antioxidants for improved skin appearance: intracellular mechanisms, challenges and future strategies. Int J Cosmet Sci. 2023;45(3):299-314 22. Fratianni F, D'Acierno A, Cozzolino A, Spigno P, Riccardi R, Raimo F, et al. Biochemical characterization of traditional varieties of sweet pepper (Capsicum annuum L.). Antioxidants (Basel). 2020;9(6):556. doi:10.3390/antiox9060556. 23. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Arch Dermatol Res. 2009;302(2):71-83. 24. Mukherjee PK, Maity N, Nema NK, Sarkar BK. Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011;19(1):64-73. doi: 10.1016/j.phymed.2011.10.003. 25. Rinnerthaler M, Bischof J, Streubel MK, Trost A, Richter K. Oxidative stress in aging human skin. Biomolecules. 2015;5(2):545-589. doi:10.3390/biom5020545. 26. Chaerunisaa AY, Surachman E, Khuzaimah Z. Peel-off gel mask containing green tea leaf extract (Camellia sinensis L.) with antioxidant activity. Indones J Pharm. 2021;3(1):1-8. 27. Koch W, Zagórska J, Marzec Z, Kukula-Koch W. Applications of tea (Camellia sinensis) and its active constituents in cosmetics. Molecules. 2019;24(23):4277. doi:10.3390/molecules24234277. 28. Michalak M. Plant extracts as skin care and therapeutic agents. Int J Mol Sci. 2023;24(20):15444. doi:10.3390/ijms242015444. 29. de Tollenaere M, Chapuis E, Lapierre L, Bracq M, Hubert J, Lambert C, et al. Overall renewal of skin lipids with vetiver extract for a complete anti-ageing strategy. Int J Cosmet Sci. 2020;43(2):165. 30. Oomah BD, Ladet S, Godfrey DV, Liang J, Girard B. Characteristics of raspberry (Rubus idaeus L.) seed oil. Food Chem. 2000;69(2):187-193. doi:10.1016/S0308-8146(99)00260-5. 31. Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, et al. Berry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem. 2006;54(25):9329-9339. doi:10.1021/jf061750g. 32. Preethi KC, Kuttan G. Anti-inflammatory activity of flower extract of Calendula officinalis. Indian J Exp Biol. 2009;47(2):113-120. 33. Ujfalusi Z, Barkó S, Hild G, Nyitrai M. Effects of formins on the conformation of subdomain 1 in actin filaments. J Photochem Photobiol B. 2010;98(1):7-11. doi: 10.1016/j.jphotobiol.2009.10.001. 34. Roelandt T, Thys B, Heughebaert C, de Vroede A, de Paepe K, Roseeuw D, et al. LEKTI-1 in sickness and in health. Int J Cosmet Sci. 2009;31(4):247-254. doi:10.1111/j.1468-2494.2009.00516. x. 35. Olisova OY, Snarskaya ES, Gladko VV, Burova EP. Russian traditional medicine in dermatology. Clin Dermatol. 2018;36(3):325-337. doi: 10.1016/j.clindermatol.2018.03.007. 36. Benson HAE, Watkinson AC. Transdermal and topical drug delivery: principles and practice. Hoboken (NJ): Wiley; 2012. 37. Chiellini E, Corti A, D'Antone S, Solaro R. Biodegradation of poly (vinyl alcohol)-based materials. Prog Polym Sci. 2003;28(6):963-1014. doi:10.1016/S0079-6700(02)00149-1. 38. Karim AA, Bhat R. Gelatin alternatives for the food industry: recent developments, challenges and prospects. Trends Food Sci Technol. 2008;19(12):644-656. doi: 10.1016/j.tifs.2008.08.001. 39. Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol. 2008;159(1):23-34. doi:10.1111/j.1365-2133.2008.08643. x. 40. Chen L, Hu JY, Wang SQ. The role of antioxidants in photoprotection: a critical review. J Am Acad Dermatol. 2012;67(5):1013-1024. doi: 10.1016/j.jaad.2012.02.009. 41. Benson HAE. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv. 2005;2(1):23-33. doi:10.2174/1567201052772915. 42. Rizzardi, N., Liparulo, I., Antonelli, G., Orsini, F., Riva, A., Bergamini, C., & Fato, R. (2021). Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells. Antioxidants 2021, Vol. 10, Page 927, 10(6), 927. https://doi.org/10.3390/antiox10060927 43. Michalak, M. (2023). Plant Extracts as Skin Care and Therapeutic Agents. International Journal of Molecular Sciences 2023, Vol. 24, Page 15444, 24(20), 15444. 44. Nemati MM, Abedi M, Ghasemi Y, Ashrafi H, Haghdel M. Formulation and evaluation of antioxidant and antibacterial activity of a peel-off facial mask moisturizer containing curcumin and Rosa damascena extract. J Cosmet Dermatol. 2024;23(6):2156-2169. 45. Winingrum LA, Zai K, Surachman E. Optimization of peel-off gel mask containing Anredera cordifolia (binahong) leaf extract using PVA–CMC–alginate combination. J Res Pharm. 2025;28(6):1953-1962. 46. Ambarwati NS, Desmiaty Y, Chandra A, Noviani Y, Triyani Y, Hakim RM, et al. Formulation of a peel-off gel mask containing Garcinia dulcis extract for antioxidant and anti-elastase activity. J Ilmu Kefarmasian Indones. 2025;23(1):58. 47. Rachmawati P, Kelvin A, Sidharta R, Lionita G, Kusuma IY. Optimization of rosella extract-based antioxidant peel-off mask using simplex lattice design. Turk J Pharm Sci. 2025;22(3):217-225. 48. Sari IM, Mahdi N, Syaiful RH. Formulation of peel-off gel mask from ethanol extract of Hibiscus rosa-sinensis leaves. J Pharm Educ Pract Technol. 2025. 49. Jamilatun M, Pratiwi MD, Yulianto S. Formulation and evaluation of peel-off face mask gel combining avocado leaf extract and jicama extract. Formosa J Sci Technol. 2024;3(8):1739-1748. 50. Parmar I, Ojha S, Sani D, Pardhe V, Gandhi Y. Natural peel-off mask formulation and evaluation. Int J Innov Sci Res Technol. 2024;9(4):474-479. 51. Patil H, Solanki K, Tare T, et al. Formulation and evaluation of multi-herb peel-off mask. Int J Pharm Sci Rev Res. 2024;84(4). 52. Lokhande S, Mankar S, Satpute A, Jadhao M. Formulation and evaluation of polyherbal peel-off mask. Asian J Pharm Res Dev. 2023;11(3). 53. Leuwisari AR, Yusuf AL. Formulation and evaluation of peel-off gel mask with tomato fruit extract using PVA base. Ad-Dawaa J Pharm. 2024;2(1). 54. Wang Y, Chen X. Application of plant extracts in cosmetics for anti-aging effects. J Dermatol Sci Cosmet Technol. 2024; 1:100014. 55. Jin Z, Zhang P, Huang H, Liu J, Jiang C, Zhang H, et al. Food-derived skincare ingredients as a promising strategy for skin aging. Colloids Surf B Biointerfaces. 2024; 244:114170. 56. He X, Gao X, Guo Y, Xie W. Research progress on bioactive factors against skin aging. Int J Mol Sci. 2024;25(7):3797. 57. Tomas M, Günal-Köroğlu D, Kamiloglu S, Ozdal T, Capanoglu E. Plant-based phytochemicals for anti-aging skin care. Immun Ageing. 2025; 22:5.