Formulation And Evaluation of Polyherbal Antidiabetic Tablet

The present study was designed to formulate and evaluate antidiabetic polyherbal tablets prepared from multiple extracts of the selected medicinal plant. Medicinal plants constitute a significant source of therapeutic agents, and numerous currently available drugs have been derived either directly or indirectly from plant sources. The formulated solid dosage form incorporated a novel dried plant extract along with pharmaceutical excipients, including starch, microcrystalline cellulose, and talc. The resulting formulation demonstrated statistically significant antidiabetic activity.Materials and Methods:The prepared tablets were subjected to standard evaluation parameters, including weight variation, friability, hardness, and disintegration time, to assess their physicochemical quality and performance characteristics.Results and Discussion:The results of the preformulation and post-compression studies indicated that all evaluated parameters were within acceptable pharmacopoeial limits. The tablets exhibited adequate hardness (3.25 ± 0.57 kg/cm²), which was sufficient to maintain structural integrity while allowing appropriate disintegration. The friability value (0.29 ± 0.03%) confirmed satisfactory mechanical stability. Given the average tablet weight of 340 mg, a weight variation limit of ±7% was considered acceptable, and the formulation complied with this specification.Conclusion:The formulated tablets successfully met the weight variation criteria. The disintegration time exceeded one minute, indicating acceptable performance; however, further investigations are required to elucidate the precise mechanism of antidiabetic action and to conduct comprehensive long-term toxicity studies to establish safety and efficacy.