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Published May 12, 2026 | Version v3

Phenotypically active ORF, CRISPR and compound consensus profiles

Authors/Creators

  • 1. Broad Institute

Description

This hosts the files of phenotypically active perturbations for JUMP, derived from https://zenodo.org/records/14025602 (ORF/CRISPR) and from the JUMP COMPOUND profiles (https://github.com/jump-cellpainting/datasets/blob/main/manifests/profile_index.json, subset 'compound') after filtering samples with no cosine-similarity matches above a given threshold (see filenames for thresholds). The compound_filtered_thresh_0_5.gct file is generated from profiles_var_mad_int_featselect_harmony.parquet by computing median consensus profiles per JCP2022 id and keeping perturbations that share cosine similarity > 0.5 with at least one other perturbation.

Files

Files (1.4 GB)

Name Size
md5:503072979fcedf61e73d9e619c33a610
1.4 GB Download
md5:eb9d3ca8e500c21f1155b62317488cbb
19.1 MB Download
md5:e69fec3c964311a91f1f1621b9aff9ab
29.1 MB Download