Nephrotic Syndrome and Cerebral Venous Sinus Thrombosis: A Case Report and Clinical Reminder

Nephrotic syndrome is associated with a hypercoagulable state and increased risk of thromboembolic events, though cerebral venous sinus thrombosis (CVST) is rare. We report a 42-year-old female with features of nephrotic syndrome who presented with generalized seizures and altered sensorium. Magnetic resonance imaging and venography revealed extensive CVST with venous infarction. Laboratory evaluation showed significant proteinuria, hypoalbuminemia, and hyperhomocysteinemia, with negative autoimmune workup. The patient was managed with low molecular weight heparin and corticosteroids, followed by oral anticoagulation, resulting in favorable clinical recovery. This case underscores the importance of early recognition of neurological manifestations in nephrotic syndrome and prompt initiation of appropriate therapy to improve outcomes.