Published May 9, 2026 | Version v1

Integrative Machine Learning for Genome Sequencing

  • 1. Shri Dharmasthala Manjunatheshwara College of Engineering & Technology, Dharwad

Description

Genomic information grows fast, pushing demand for better tools to handle DNA analysis precisely. Studying genetic code helps uncover differences in genes, links across species, also clues behind illnesses. Still, working through massive amounts of biological data means finding ways to align sequences quickly without losing precision. This work examines how computers analyze DNA sequences by applying standard tools in bioinformatics. Instead of general scans, one method digs into matching segments using BLAST, known for speed when handling vast genetic collections. Precision comes another way - Smith–Waterman builds alignments step by step via dynamic programming. Although slower, it leaves little room for error in spotting local matches. Speed versus accuracy splits the choice between them depending on task demands. This study examines current techniques while introducing a refined hybrid method aimed at boosting DNA sequence processing speed. Following initial fast scanning through BLAST, the system applies Smith–Waterman for precise local matching. Beyond that, pattern detection gains support from a probabilistic layer via Hidden Markov Models. Though slower methods exist, tools like BLAST aim at speed when scanning vast genetic datasets. By spotting small matching segments first, then building outward, computation time drops sharply. Its approach trades perfect precision for efficiency - optimal matches sometimes missed. Unlike exact techniques rooted in dynamic programming, this method prioritizes practicality over completeness.

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