Role Of Statin Therapy In Preventing Capsular Contracture After Breast Augmentation

PURPOSE: Simvastatin has been shown to reduce capsular contracture around silicone implants in rat models 1 . This relationship has not been evaluated in humans. This study sought to evaluate the effect of statins on development of capsular contracture after breast augmentation. METHODS: This retrospective review of the TriNetX Analytics Network queried the Global Collaborative Network with over 170 million patients to identify patients undergoing breast augmentation with implants. Patients under 18 years of age were excluded.We included both lipophilic (simvastatin, atorvastatin, lovastatin, fluvastatin, pitastatin) and hydrophilic statin classes (rosuvastatin, and pravastatin). Patients were propensity score matched for demographics, history of smoking, BMI, A1C, hypertension, hyperlipidemia, diabetes mellitus, history of acute or chronic myocardial infarction, cholesterol, LDL, HDL, triglyceride categories, and metabolic disorders. Patients were identified using diagnosis and procedure codes. Development of capsular contracture were compared between 1:1 propensity score matched cohorts. ratios and T-tests were used to compare outcomes. RESULTS: A total of 2,052 patients who underwent breast augmentation and received a statin within 1 year before surgery were matched to 2,052 patients who did not receive statin therapy from an original pool of 77,092. Patients who received statin therapy were less likely to develop capsular contracture 1 year (p<0.05) and 3 years (p<0.05) after surgery. Additionally, patients who received statins were less likely to undergo capsulectomy (p<0.05). CONCLUSIONS: Patients undergoing breast augmentation with implants who received statin therapy preoperatively were less likely to develop capsular contracture and undergo capsulectomy. This study establishes the role of statin therapy in decreasing capsular contracture rates in patients undergoing breast augmentation with implants. *Source: https://ps-rc.org/meeting/Program/2026/AS116.cgi*