ASAP Data Repository
Published May 31, 2026 | Version v1.0
Dataset Open

PD5D midbrain single-nucleus RNA-seq hybrid selection

Authors/Creators

  • 1. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
  • 2. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510, USA,& APDA Center for Parkinson Precision Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Genetics, Yale, New Haven, CT 06510, USA
  • 3. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510, USA; APDA Center for Parkinson Precision Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Genetics, Yale, New Haven, CT 06510, USA
  • 4. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510, USA
  • 5. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Precision Neurology Program of Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
  • 6. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Banner Sun Health Research Institute, Sun City, AZ 85351, USA
  • 7. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510, USA; APDA Center for Parkinson Precision Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA
  • 8. Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA; Stephen & Denise Adams Center for Parkinson's Disease Research of Yale School of Medicine, New Haven, CT 06510, USA; APDA Center for Parkinson Precision Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale, New Haven, CT 06510, USA
  • 9. Broad Clinical Labs, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Description

This dataset contains raw FASTQ files from the midbrain single-nucleus RNA sequencing (snRNAseq) dataset with hybrid selection for the matching PMDBS samples from the PD5D chort. The same subjects were also profiled with other omics assays including genomic DNAseq, genotyping, single-cell ATACseq, and spatial transcriptomics.

Files

scherzer-pmdbs-sn-rnaseq-midbrain-hybsel_README.pdf

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Additional details

References