Published May 7, 2026
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TYPE 2 DIABETES MELLITUS: GLOBAL EPIDEMIOLOGICAL TRENDS, MOLECULAR MECHANISMS AND RISK FACTORS WITH SPECIAL REFERENCE TO UZBEKISTAN
Authors/Creators
- 1. Master student at Andijan state medical institute
- 2. doctor endocrinologist at Republican Scientific and Practical Medical Center of Endocrinology
- 3. Head of the department pharmaceutical science Andijan state medical institute
Description
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia resulting from insulin resistance, impaired insulin secretion, or a combination of both mechanisms. It represents approximately 90–95% of all diabetes cases and is associated with a wide spectrum of microvascular and macrovascular complications that significantly increase morbidity and mortality worldwide. Due to its progressive nature and multisystem involvement, T2DM has become one of the most pressing global public health challenges of the 21st century.
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References
- 1.International Diabetes Federation (2021) IDF Diabetes Atlas. 10th edn. Brussels: IDF.
- 2.American Diabetes Association (2025) 'Standards of Care in Diabetes—2025', Diabetes Care, 48(Suppl 1), pp. S1–S350.
- 3.Zheng, Y., Ley, S.H. and Hu, F.B. (2018) 'Global aetiology and epidemiology of type 2 diabetes mellitus and its complications', Nature Reviews Endocrinology, 14(2), pp. 88–98.
- 4.DeFronzo, R.A., Ferrannini, E., Groop, L. et al. (2015) 'Type 2 diabetes mellitus', Nature Reviews Disease Primers, 1, 15019.
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