UNLOCKING THE ANTICANCER EFFICACY OF 4-HYDROXY-3-METHOXY CINNAMIC ACID: A PREDICTIVE COMPUTATIONAL STUDY FOR DRUG DEVELOPMENT

Background: Cancer remains a significant global health challenge, high failure rate in oncology therapeutic development necessitates novel approaches to model drug response and resistance. 4-Hydroxy-3-methoxy cinnamic acid (FA) is naturally occurring phenolic compounds found in various plants, have demonstrated significant in vitro and in vivo anticancer potential by targeting multiple molecular pathways, including apoptosis induction, tyrosine kinase inhibitor and cell cycle arrest.

Objective: This study utilizes a sophisticated computational study approaches docking simulations were, to investigate the molecular interactions and mechanisms by which 4-Hydroxy-3-methoxy cinnamic acid derivative exert their anticancer activities, focusing on predicting drug responses as anticancer or identifying novel biomarkers.