FORMULATION AND CHARACTERIZATION OF STOMACH SPECIFIC DRUG DELIVERY SYSTEM OF NIZATIDINE

Floating drug delivery systems (FDDS) or hydro-dynamically balanced systems have a bulk density lower than gastric fluids and thus remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the stomach. After the release of the drug, the residual system is emptied from the stomach.