CREST: A Concept for Electronics-Free, pH-Triggered Emergency Drug Delivery in Refractory Epilepsy

This concept note proposes CREST — a subcutaneous implant designed to deliver emergency benzodiazepine medication during generalised tonic-clonic seizures without electronics or external triggers. The mechanism relies on seizure-induced lactic acidosis as a physiological trigger for pH-sensitive polymer erosion and controlled midazolam release. This document is an early-stage concept intended to establish date of priority and invite technical critique.