Published May 1, 2026 | Version v1

Data accompanying manuscript: A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation

Description

This repository contains the analyzed datasets, codes, uncut gel pictures of western blots, and plasmid maps for the manuscript "A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation". Analyzed Droplet Hi-C datasets are stored in the folder "DropletHiC_analyzed_data"; Analyzed 3C-HTGTS,  CUT&RUN, ChIP-seq and TT-TimeLapse-seq datasets are stored in the folder "Sequencing_analyzed_bigWig_data"; Analyzed MINA and chromatin tracing datasets are stored in the folder "Imaging_analyzed_data"; codes for Droplet Hi-C and imaging data analysis are stored in the folder "Codes". The plasmid maps are stored in the folder "PlasmidMap".

Files

Codes.zip

Files (69.3 GB)

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Additional details

Funding

National Institutes of Health
Genome Architecture in Human Germinal Center B Cell Development, Malignancy, and Somatic Hypermutation U01CA260701

Dates

Submitted
2026-05-01