EFFICACY OF CURRENT DRUGS AGAINST SOIL-TRANSMITTED HELMINTHS
Authors/Creators
- 1. V.Y. Akhundov Scientific Research Institute of Medical Preventive Medicine
Description
Soil-transmitted helminth (STH) infections are among the most widespread parasitic diseases worldwide, with children being particularly at risk. Drugs belonging to the benzimidazole group, such as albendazole and mebendazole, are widely used in preventive chemotherapy and play a significant role in reducing morbidity. However, in recent years, resistance to these drugs has emerged as a concern. Fecal egg count reduction tests (FECRT) and mutations in the β-tubulin gene (F200Y, F167Y, E198A) are used as primary indicators. Results show that albendazole and mebendazole maintain high efficacy against Ascaris
lumbricoides, but their effectiveness against Trichuris trichiura and Hookworm infections has decreased in some regions.
Combination therapies (albendazole + ivermectin/oxantel pamoate) demonstrate higher efficacy than monotherapy, with egg reduction rates of 82–95%. Monitoring of antihelminthic drugs and implementing combination treatment strategies are essential to prevent resistance and achieve the 2030 targets for the elimination of geohelminth infections.
Abstract (Azerbaijani)
Geohelmintozlar dünyada geniş yayılmış parazitar xəstəliklərdəndir, xüsusilə uşaqlar ən çox risk altındadır. Albendazol və mebendazol kimi benzimidazol qrupuna aid dərmanlar profilaktik kimyaterapiyada geniş istifadə olunur və xəstələnmənin azalmasında əhəmiyyətli rol oynayır. Lakin son illərdə bu dərmanlara qarşı rezistentlik problemləri yaranmışdır.
Fekal yumurta sayının azalması testi (FECRT) və β-tubulin genindəki mutasiyalar (F200Y, F167Y, E198A) əsas göstəricilər kimi istifadə olunur. Nəticələr göstərir ki, albendazol və mebendazol Ascaris lumbricoides-a qarşı yüksək effektivliyini saxlayır, lakin Trichuris trichiura və Ankilostomidozlarda effektivlik bəzi regionlarda azalmışdır.
Kombinə terapiyalar (albendazol + ivermektin/oxantel pamoat) monoterapiyadan daha yüksək effektivlik göstərir (yumurta sayının azalması 82–95%). Antihelmint preparatların monitorinqi və dərman kombinasiya strategiyalarının tətbiqi rezistentliyin qarşısını almaq və 2030-cu il üçün geohelmintozların eliminasiyası hədəflərinə nail olmaq üçün vacibdir.
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Annali d’Italia №78 2026-61-64.pdf
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Additional details
Additional titles
- Alternative title (Azerbaijani)
- GEOHELMİNTOZLARA QARŞI MÖVCUD DƏRMANLARIN EFFEKTİVLİYİ
References
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