Development of recyclable Heterogeneous nano-catalysts for the green one-pot synthesis of Thiazole derivatives via multicomponent cyclization reaction

Abstract

The green methodology for the one-pot synthesis of thiazole derivatives via a multicomponent cyclization reaction has been developed, utilizing a recyclable heterogeneous nano-catalyst. Multicomponent reactions are effective synthetic methods that decrease waste production and enhance atom economy [1,2]. Because of their wide range of biological activities, thiazole-containing heterocycles are significant structural motifs in materials and medicinal chemistry [3,4]. Using heterogeneous nanocatalysts, the current work produced thiazole compounds in high yields and good selectivity by reacting substituted aldehydes, thiosemicarbazide, and α-halo ketones under mild circumstances. FT-IR, XRD, SEM/TEM, and EDX investigations verified the catalysts' structural stability and nanoscale shape, which is in line with earlier findings on nanostructured catalytic materials [5,6]. High surface area and enhanced catalytic effectiveness are well-known benefits of zirconia-based nanocatalysts and metal nanoparticles supported by graphene oxide [7–10]. The benefits of green nanocatalysis were highlighted by the catalyst's outstanding catalytic activity, straightforward product isolation, and efficient recyclability over several cycles [11–15]. This ecologically friendly and cost-effective method for synthesizing physiologically significant thiazole scaffolds is offered by this sustainable heterogeneous catalytic system.