Ayurvedic-derived withanoside compounds for stress-resistant extramammary Paget disease

Withanoside compounds from Withania somnifera (Ashwagandha) in Ayurvedic medicine can modulate stress response pathways and have demonstrated anti-cancer properties. Given the chronic nature of EMPD and potential stress-related immune dysfunction, adaptogenic compounds could provide supportive therapy. These compounds may interact with pathways involving TP53 (0.28 in Open Targets) through stress response modulation.