Published April 28, 2026 | Version v1
Preprint Open

CRISPR prime editing for in-vivo IVD gene correction

Authors/Creators

  • 1. MedicOath

Description

Prime editing technology enables precise correction of IVD gene mutations without double-strand breaks, using pegRNA to install correct sequences. Liver-targeted AAV delivery ensures hepatic IVD restoration for systemic metabolic correction.

Notes

IPFS: QmNwgQ6tDWPBTYNEFdiNfEz3QjUfZwQjvm1x8rwChuzF3P. TX: 0xce6d9103daf4a642e5a3bc12dee3c5aa9a4a696b996cd6bf1cb92f3eb5111143. CC0.

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