Published April 28, 2026 | Version v1
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Rapamycin-Induced Autophagy for Ganglioside Aggregate Clearance

Authors/Creators

  • 1. MedicOath

Description

Rapamycin inhibits mTORC1 signaling, leading to ULK1 activation and initiation of macroautophagy. Enhanced autophagic flux could facilitate clearance of GM2 ganglioside storage vesicles and aggregated proteins in Tay-Sachs neurons through lysosomal fusion and bulk degradation mechanisms, bypassing the specific HEXA enzyme deficiency.

Notes

IPFS: QmWV9AnmGFSxKzpaQqgcNdSBugPFqaSh3jWSerE35i7eXu. TX: 0xb9f2d56b426c8d25a173faec8c4b390537abd7dda8921152944b929310211e65. CC0.

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