Published April 28, 2026 | Version v1
Preprint Open

PDE4D Inhibition with Repurposed Anti-Inflammatory Agents

Authors/Creators

  • 1. MedicOath

Description

Target PDE4D (evidence score 0.36 from Open Targets) which regulates cAMP levels. FAERS data shows unexpected co-reporting of anti-inflammatory drugs (diclofenac sodium: 8 reports, ibuprofen: 3 reports) with Fragile X syndrome, suggesting potential beneficial modulation of neuroinflammatory pathways through PDE4D inhibition.

Notes

IPFS: QmeGim3T35xEhsftF23cqJwUYPyvPBRtPn1HLHHMwxYk1g. TX: 0x4a3e17166394a4ec25cc517c6b2643a763dad1ec6994b5677c2590c019cbb795. CC0.

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