Harpagophytum procumbens Extract for Autoimmune Inner Ear Disease via Complement Cascade Inhibition

Harpagoside and harpagide from African Devil's Claw (Harpagophytum procumbens) selectively inhibit complement component C5a receptor and reduce complement-mediated inflammation in the inner ear. The compounds also modulate T-regulatory cell function through TGF-β pathway activation and inhibit autoantibody production against inner ear antigens like cochlin and collagen type II. This provides a novel approach to autoimmune sensorineural hearing loss.