Published April 28, 2026
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Ashwagandha Withanolide D for Androgen Receptor-Mediated Ductal Development
Description
Withanolide D from Withania somnifera acts as a selective androgen receptor modulator, enhancing AR nuclear translocation and transcriptional activity specifically in reproductive ductal tissues. It promotes expression of HOX genes (particularly HOXA10 and HOXA11) essential for Wolffian duct development while upregulating anti-Müllerian hormone receptor signaling pathways.
Notes
IPFS: QmXjBPquDSYD1ELJe6MnkShdqgs3BS4wD2AT4tpH4ZkEQd. TX: 0x550a95c773af20f39e40f12a5f90eec69081344fe33ae54c89f1eee02486dd4d. CC0.
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hypothesis.json
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(408 Bytes)
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