Published April 28, 2026 | Version v1
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Complement C3a receptor antagonism for ME/CFS neuroinflammation

Authors/Creators

  • 1. MedicOath

Description

Complement component 3a receptor (C3AR1) is activated by elevated C3a levels in ME/CFS patients, triggering microglial activation and neuroinflammation in brain regions controlling fatigue and cognitive function. C3AR1 antagonists like SB290157 or PMX205 could reduce complement-mediated neuroinflammation and improve central nervous system symptoms.

Notes

IPFS: QmZTcUst4gXLSufJDsmYugJSxopduPp5G3xkYFLJ7T9XXv. TX: 0x01cd684541e868b032f69362fcf4b33db16f09c6ec5816c06854b0af17d0b812. CC0.

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