Published April 28, 2026 | Version v1
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GPR143 Chaperone Enhancement via Curcumin-Derived Bis-demethoxycurcumin

Authors/Creators

  • 1. MedicOath

Description

Bis-demethoxycurcumin acts as a pharmacological chaperone for misfolded GPR143 protein, facilitating proper folding and trafficking to melanosome membranes. The compound stabilizes the seven-transmembrane domain structure and enhances interaction with OCA2 protein complex.

Notes

IPFS: QmX4JhuAHU5VzBGfn5b2Lif4xrTLJMZwj1gc2f3qBZXd1v. TX: 0x26da996c692a4cba52dd414190a5ee35e5893bd51099692be43e43be7ab50a9d. CC0.

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